多肽定制產(chǎn)品的鹽類(lèi)型，不僅影響多肽的溶解性和穩定性，有時(shí)也具有部分生物毒性。所以選擇合適的鹽類(lèi)型，對實(shí)驗的成功至關(guān)重要。Supertide可以提供的鹽類(lèi)型有：
The salt types of polypeptide products not only affect the solubility and stability of polypeptides, but also have partial biotoxicity. So choosing the right type of salt is crucial to the success of the experiment. The types of salt that Supertide can provide are
鹽類(lèi)型 | 特點(diǎn)或用途 |
三氟乙酸鹽 TFA | 多肽產(chǎn)品通常為三氟乙酸鹽。由于三氟乙酸的生物毒性較大，部分實(shí)驗需要避免此鹽類(lèi)型。 Polypeptide products are usually trifluoroacetate. Because of the high biotoxicity of trifluoroacetic acid, this salt type should be avoided in some experiments. |
醋酸鹽 Ac | 由于醋酸的生物毒性小，大部分藥物肽或美容肽為醋酸鹽。但部分產(chǎn)品的醋酸鹽穩定性不佳，需要考慮序列穩定性。 Because of the low biotoxicity of acetic acid, most drug peptides or beauty peptides are acetate. However, the acetate stability of some products is not good, so the sequence stability should be considered. |
鹽酸鹽 HCl | 較少產(chǎn)品會(huì )選擇鹽酸鹽。部分序列由于特殊用途，需要采用鹽酸鹽 Less products will choose the hydrochloride. Some sequences require the use of hydrochloride for specific purposes |
銨鹽 NH4+ | 會(huì )嚴重影響產(chǎn)品的溶解性和穩定性，需要根據序列進(jìn)行選擇。 It will seriously affect the solubility and stability of the product, which needs to be selected according to the sequence. |
鈉鹽 Na+ | 通常會(huì )影響產(chǎn)品的溶解性和穩定性 This usually affects the solubility and stability of the product |
雙羥萘酸鹽 Pamoic acid | 雙羥萘酸鹽通常用于多肽藥物制作緩釋劑 Dihydroxynaphthenate is commonly used in the production of peptide drugs as a sustained-release agent |
檸檬酸鹽 Citric Acid | 生物毒性較小，但由于制備工藝較復雜，需要根據序列單獨開(kāi)發(fā)生產(chǎn)工藝 Biotoxicity is relatively low, but due to the complexity of the preparation process, it is necessary to develop the production process separately according to the sequence |
水楊酸鹽 Salicylic acid | 影響多肽產(chǎn)品的穩定性，較少采用 Affect the stability of polypeptide products, less used |